CV

Education

• Doctor of Philosophy, Biostatistics & Data Science
  • The University of Kansas School of Medicine , Kansas City, KS
  • Enrolled: 2017.08 - Expected 2021.06
• Master of Science, Statistics
  • The University of Nevada, Reno
  • Enrolled: 2015.08 - 2017.06
• Bachelor of Science, Mathematics
  • University of Dhaka, Bangladesh
  • Enrolled: 2010.01 - 2014.06

Research Interest

Interim Monitoring; Survival Analysis; Bayesian Clinical trial Design; Linear/Non Linear Mixed effects model; Machine Learning; Alzheimer’s disease.

Research Experience:

• University of Kansas Cancer Center (KUCC): August 2019 - Dec 2019
• The University of Kansas Medical Center
  • Exploratory visualization of KUCC catchment area data.
  • Used the Generalized estimating equation (GEE) to model the catchment data.
  • the goal is to determine how KUCC hospital facilitate to improve the cancer in rural and urban population in Kansas.
• Department of Nephrology and Hypertension : August 2018 - Present
• The University of Kansas Medical Center
  • Develop a statistical model on geriatric nephrology with a focus on cognitive impairment and quality of life in patients with kidney diseases
  • Studying cognitive function before and after kidney transplantation and the adverse effects of immune suppression on cognition and quality of life.
  • the Effects on access to kidney transplantation, especially for older patients with the end-stage renal disease.
• The University of Kansas Alzheimer disease Center: August 2017 - Present
  • Working collaboratively with Alzheimer disease center to develop in-depth statistical analysis on identified areas of concern.
  • Participate with researchers in the development of research methodology and study design.
  • Compile and analyze data on performances metrics from multiple data source in order to validate and standardize logic used across the platform.

Teaching Experience

• Graduate Teaching Assistant August 2017 - 2018
• Department of Biostatistics, The University of Kansas Medical Center.
  • Taught course BIOS 740 Applied Multivariate Methods (Fall 2018) , STAT 820 Statistical Computing (Summer 2017).
  • Served as a consultant in the biostatistics tutoring lab every other Friday to answer questions from students from various medical programs at the KU medical center.
• Graduate Teaching Assistant August 2015 - July 2017
• Department of Mathematics and Statistics, The University of Nevada, Reno
  • Course taught including Probability and Statistics, Advanced Calculus, Pre Calculus - I,II for Undergrad Students.
  • Created lesson plans and fostered an environment conducive to facilitate students furthering their education.
  • Proctored, graded and recorded quizzes and exams

Project

• Bayesian Adaptive clinical trial with Interim Analysis: August 2019 - ongoing.
  • Frequentest and Bayesian look at the data and data driven modification of the trial.
  • Extensive use of simulation to adjust characteristics of trial design.
  • Comparative statistical analysis of various methods used for interim analysis based on final endpoint.
• Identify the association of the haplogroup-defining mito chondri al SNPs with the Alzheimer’s disease risk: January 2019 - ongoing
  • explore how the SNPs assayed at baseline is associated with the disease progression over time as measured by diagnosis based on the change in MMSE and DR, and other factors.
  • explore such association differs further with respect to the APOE e4 status(interaction).
• Donor kidney transplantati on using flexible parametric and semi-parametric statistical model: August 2018 - August 2019
  • Fitted a Cox proportional hazard model for Kidney transplant data.
  • Conducted 10-fold cross validation based on overall C index as a measure of discrimination to validate the proposed Cox proportional hazard model.
• Predicting hospitalization 30-Day Readmission: Kidney t ransplant disease : August 2017 - Dec 2017
  • Built a logistic model for prediction modeling using readmission data
  • Conduct cross validation analysis using different statistical method.
• Developing R shiny web application for int egra ting electronic data capture and data management: August 2018 - August 2019
  • Using open source software Redcap, R-studio to develop R shiny app for real time data visualization and reporting for Alzheimer’s disease.
  • Using for weekly consensus meeting to evaluate the patient with dementia or not.
• Cost-Benefit effectiveness analysis with Statistical Markov Mo deling approach: Dec. 2016 - July 2017
  • Analyzed knee transplant data using deterministic and probabilistic Markov model and compare the effectiveness with net-benefit framework.
  • Also done Uncertainty quantification and sensitivity analysis using probabilistic Markov modeling.
• Data Analysis Project: August 2015 - present
  • Titanic Survival data analysis.
  • Write sample NIH grant to access the effectiveness of turmeric on coronary heart related diseases (Class Project).
  • Forecasting with Time series models with stock exchange data.(Class Project).
  • Analysis of case control study design with panel data. (Class Project)
  • Wrote sample protocol for a hypothetical clinical trial as a part of Clinical trial class project

Skills

• R for Statistical Analysis software
• SAS suite of analytics, , SAS Macro language, SAS/GRAPH
  • PROC SQL
  • SAS Macro language
  • SAS/GRAPH
• JMP
• SPSS
• Others : Tableau, MYSQL, Redcap, Mathematica

Publications

Generalized Univariate Distributions and a New Asymmetric Laplace Model

Sharma, Palash. "Generalized Univariate Distributions and a New Asymmetric Laplace Model." arXiv preprint arXiv:2005.05101 (2020).

Assessing accuracy of Weibull shape parameter in clinical trials for time-to-event outcome

Phadnis, Milind A., Palash Sharma, Nadeesha Thewarapperuma, and Prabhakar Chalise. "Assessing accuracy of Weibull shape parameter estimate from historical studies for subsequent sample size calculation in clinical trials with time-to-event outcome." Contemporary Clinical Trials Communications (2020): 100548.

Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity After Kidney Transplantation

Lepping, Rebecca J., Robert N. Montgomery, Palash Sharma, Jonathan D. Mahnken, Eric D. Vidoni, In-Young Choi, Mark J. Sarnak, William M. Brooks, Jeffrey M. Burns, and Aditi Gupta. "Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity After Kidney Transplantation." medRxiv (2020).

Exploratory analysis of mtDNA haplogroups in two Alzheimer’s longitudinal cohorts

Swerdlow, Russell H., et al. "Exploratory analysis of mtDNA haplogroups in two Alzheimers longitudinal cohorts." Alzheimers & Dementia 16.8 (2020): 1164-1172.

Mild cognitive impairment is associated with skeletal muscle mitochondrial deficits (Under Review)

Morris, Jill K., Colin S. McCoin, Kelly N. Fuller, Casey S. John, Heather M. Wilkins, Xiaowan Wang, Palash Sharma et al. "Mild cognitive impairment is associated with skeletal muscle mitochondrial deficits." medRxiv (2020).

The influence of religious belief on burnout in medical students

Haghnegahdar, Megan et al. “The Influence of Religious Belief on Burnout in Medical Students.” Missouri medicine vol. 118,1 (2021): 63-67.

CONSENSUS: A Shiny application of Dementia evaluation and reporting for the KU ADC Longitudinal Clinical Cohort Database

Sharma, Palash, Robert N. Montgomery, Rasinio S. Graves, Kayla Meyer, Suzanne L. Hunt, Eric D. Vidoni, Jonathan D. Mahnken, Russell H. Swerdlow, Jeffrey M. Burns, and Dinesh Pal Mudaranthakam. "CONSENSUS: A Shiny application of Dementia evaluation and reporting for the KU ADC Longitudinal Clinical Cohort Database." (2020).

CERTIFICATION 09/16/2017 - present

• Collaborative Institutional Training Initiative(CITI) Certificate for Biomedical Researchers.
• Collaborative Institutional Training Initiative(CITI) Certificate for Responsible conduct of Research.

HONORS AWARDS

• Midwest SAS conference Scholarship Indianapolis, Indiana   September 30, 2018 - October 2, 2018
• SCSUG Educational Forum Scholarship Austin, TX   November 4, 2018 - November 7, 2018
• Graduate Research Assistantship Department of Biostatistics & Data Science, KUMC   August 2017-present
• Graduate Teaching Assistant, Department of Mathematics and Statistics, UNR   August 2015 - May 2017
• Bangladesh Science and Technology Scholarship (Govt. of Bangladesh)   May 2012- May 2013

COMMUNITY SERVICE

• Midwest SAS Global conference, (Indianapolis, Indiana), Volunteer   September 30, 2018 - October 2, 2018
• Graduate Student association at UNR (Member), Volunteer   August 2015 - May 2017
• President of Bangladesh student association at UNR, Volunteer   December 2016 - May 2017
• Vice President, KUMC biostatistics Student Group, Volunteer   August 2017 - August 2018
• Graduate Student Association at Ku Medical Center, Volunteer   August 2017 - Present

PROFESSIONAL MEMBERSHIP

• American Statistical Association.
• Kansas-Western Missouri Chapter of ASA.